Molecular Basis

 Let us recapitulate the chemical structure of a polynucleotide chain (DNA or RNA). A nucleotide has three components – a nitrogenous base, a pentose sugar (ribose in case of RNA, and deoxyribose for DNA), and a phosphate group. There are two types of nitrogenous bases – Purines (Adenine and Guanine), and Pyrimidines (Cytosine, Uracil and Thymine). Cytosine is common for both DNA and RNA and Thymine is present in DNA. Uracil is present in RNA at the place of Thymine. A nitrogenous base is linked to the OH of 1' C pentose sugar through a N-glycosidic linkage to form a nucleoside, such as adenosine or deoxyadenosine, guanosine or deoxyguanosine, cytidine or deoxycytidine and uridine or deoxythymidine. When a phosphate group is linked to OH of 5' C of a nucleoside through phosphoester linkage, a corresponding nucleotide (or deoxynucleotide depending upon the type of sugar present) is formed. Two nucleotides are linked through 3'-5' phosphodiester linkage to form a dinucleo...

 About 15 mya, primates called Dryopithecus and Ramapithecus were existing. They were hairy and walked like gorillas and chimpanzees. Ramapithecus was more man-like while Dryopithecus was more ape-like. Few fossils of man-like bones have been discovered in Ethiopia and Tanzania. These revealed hominid features leading to the belief that about 3-4 mya, man-like primates walked in eastern Africa. They were probably not taller than 4 feet but walked up right. Two mya, Australopithecines probably lived in East African grasslands. Evidence shows they hunted with stone weapons but essentially ate fruit. Some of the bones among the bones discovered were different. This creature was called the first human-like being the hominid and was called Homo habilis. The brain capacities were between 650-800cc. They probably did not eat meat. Fossils discovered in Java in 1891 revealed the next stage, i.e., Homo erectus about 1.5 mya. Homo erectus had a large brain around 900cc. Homo erectus probably...

 About 2000 million years ago (mya) the first cellular forms of life appeared on earth. The mechanism of how non-cellular aggregates of giant macromolecules could evolve into cells with membranous envelop is not known. Some of these cells had the ability to release O2 . The reaction could have been similar to the light reaction in photosynthesis where water is split with the help of solar energy captured and channelised by appropriate light harvesting pigments. Slowly single-celled organisms became multi-cellular life forms. By the time of 500 mya, invertebrates were formed and active. Jawless fish probably evolved around 350 mya. Sea weeds and few plants existed probably around 320 mya. We are told that the first organisms that invaded land were plants. They were widespread on land when animals invaded land. Fish with stout and strong fins could move on land and go back to water. This was about 350 mya. In 1938, a fish caught in South Africa happened to be a Coelacanth which ...